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Other hand, in the duration of tooth chattering and threat posture were higher than those in the control group. No significant difference was observed between the leaded and unleaded gasoline.Table 3: Effect of chronic exposure to two types of gasoline vapour on the content of monoamines (g/g) in the hippocampus of male ratsParameter GROUP Control Leaded gasoline Unleaded gasoline Norepinephrine 0
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Lusions: Early limited exposure to nitrosamines exacerbates the adverse effects of later chronic high dietary fat intake in promoting T2DM and neurodegeneration. The mechanism involves increased generation of ceramides and probably other toxic lipids in brain.Background The prevalence rates of Alzheimer's Disease (AD), Parkinson's disease (PD), obesity, type 2 diabetes mellitus (T2DM), and metabol
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Athione S -transferase activity, and lipid peroxidation was observed in liver and brain. Exposure to toluene, one of the gasoline constituents, both in vivo and in vitro, leads to reactive oxygen species formation in many tissues including brain tissue [36-38]. The study of Calder -Guzm et al [39] revealed that the aldehydes resulting from the oxidation of the methyl groups in the aromatic compou
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Nd norepinephrine were elevated above the control level. Data in table 5 reveal that Na+, K+-ATPase activity and total protein content in the two groups exposed to gasoline were lower than the control, although no significant difference was found between each other. The rats exposed to the unleaded gasoline had a significantly lower acetylcholinesterase activity as compared with the control or lea
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Ed as means ?SD a: significantly different from the control group. b: significantly different from the leaded gasoline. Asterisks indicate the level of significance (* P
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D that volatile solvents such as benzene, a main constituent of gasoline fuel, seems to interact with the synthesis and catabolism of catecholamines and serotonin in the brain, which might explain the neurotoxic effects of these solvents [53]. In this regard, deficiencies of serotonin or other monoamine neurotransmitters such as dopamine and norepinephrine are linked with depression [54,55]. In re
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Ecules or to relative reduction in acetylcholinesterase-containing neurons, thus potentiating cholinergic effects. In the present study, no statistical differences were detected among the serotonin levels of the cerebral cortex in the three groups; the control, the leaded and the unleaded. However, in the hypothalamus, hippocampus, cerebellum, the serotonin level was lower in the groups exposed to
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Ither the leaded or unleaded group as compared with the control. On the contrary, dopamine was elevated in the cerebellum of leaded exposed group above both the unleaded gasoline and control. The fluctuations in the levels of dopamine in different brain areas may be related to the effects MMT which is an organic manganese (Mn) compound added to unleaded gasoline and the mechanisms of Mn neurotoxic

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